PUBLICATIONS

An efficient, scarless, selection-free technology for phage engineering

Moran G. Goren, Tridib Mahata, Udi Qimron | RNA Biology, in press, 2023

Inhibition of Host Cell Division by T5 protein 008 (Hdi)

Tridib Mahata, Shahar Molshanski-Mor, Moran G. Goren, Miriam Kohen-Manor, Ido Yosef, Oren Avram, Dor Salomon, Udi Qimron | Microbiology Spectrum, in press, 2023

Highly Active CRISPR-Adaptation Proteins Revealed by a Robust Enrichment Technology

Ido Yosef, Tridib Mahata, Moran G. Goren, Or J. Degany, Adam Ben-Shem, and U Qimron | Nucleic Acids Research, in press, 2023097

Characterization of antibiotic resistomes by reprogrammed bacteriophage-enabled functional metagenomics in clinical strains

Apjok G, Számel M, Christodoulou C, Seregi V, Vásárhelyi BM, Stirling T, Eszenyi B, Sári T, Vidovics F, Nagrand E, Kovács D, Szili P, Lantos II, Méhi O, Jangir PK, Herczeg R, Gálik B, Urbán P, Gyenesei A, Draskovits G, Nyerges Á, Fekete G, Bodai L, Zsindely N, Dénes B, Yosef I, Qimron U, Papp B, Pál C, Kintses B. | Nature Microbiology, 8(3):410-423, 2023

A novel phage mechanism for selective nicking of dUMP-containing DNA

Mahata T, Molshanski-Mor S, Goren MG, Jana B, Kohen-Manor M, Yosef I, Avram O, Pupko T, Salomon D, and Qimron U. | Proc Natl Acad Sci U S A, 118(23):e2026354118, 2021

Rapid seroconversion and persistent functional IgG antibodies in severe COVID-19 patients correlates with an IL-12p70 and IL-33 signature

A Munitz, L Edry-Botzer, M Itan, R Tur-Kaspa, D Dicker, D Markovitch, M Goren, M Mor, S Lev, T Gottesman, K Muhsen, D Cohen, M Stein, U Qimron, N Freund, Y Wine, M Gerlic | Scientific Reports, 11(1):3461, 2021

Phage T7 DNA mimic protein Ocr is a potent inhibitor of BREX defence.

Isaev A, Drobiazko A, Sierro N, Gordeeva J, Yosef I, Qimron U, Ivanov NV, Severinov K. | Nucleic Acids Res., 48(13):7601-7602, 2020

A continuous evolution system for contracting the host range of bacteriophage T7

Holtzman T, Globus R, Molshanski-Mor S, Ben-Shem A, Yosef I, and Qimron U | Scientific Reports, 10(1):307, 2020

**Top 50 downloads in Microbiology section

A genetic system for biasing the sex ratio in mice

Yosef I, Edry-Botzer L, Globus R, Shlomovitz I, Munitz A, Gerlic M, and Qimron U | EMBO Reports, (8):e48269, 2019

News and Views by David Zarkower and Michael Smanski in EMBO Rep – same issue

Global phylogeography and ancient evolution of the widespread human gut virus crAssphage

Robert Edwards +117 co-authors including Qimron U | Nature Microbiology, 4(10):1727-1736, 2019

Activated Eosinophils Exert Antitumorigenic Activities in Colorectal Cancer

GReichman H, Itan M, Rozenberg P, Yarmolovski T, Brazowski E, Varol C, Gluck N, Shapira S, Arber N, Qimron U, Karo-Atar D, Lee JJ, Munitz A | Cancer Immunol Res., 7(3):388-400, 2019

Optimizing DNA transduction by selection of mutations that evade bacterial defense systems

Auster O, Globus R, Yosef I, and Qimron U | RNA Biology, 16(4):595-599, 2019

T7 phage factor required for managing RpoS in Escherichia coli

Tabib-Salazar A, Liu B, Barker D, Burchell L, Qimron U, Matthews SJ, Wigneshweraraj S. | Proc Natl Acad Sci U S A. Jun 5;115(23):E5353-E5362, 2018

CRYSTAL-CLEAR MEMORIES OF A BACTERIUM

Globus R., Qimron U. | Science. 2017 Sep 15;357(6356):1096-1097

SELECTION OF GENETICALLY MODIFIED BACTERIOPHAGES USING THE CRISPR-CAS SYSTEM

Manor M., Qimron U. | Bio Protoc. 2017 Aug 5;7(15). pii: e2431. doi: 10.21769/BioProtoc.2431

A TECHNOLOGICAL AND REGULATORY OUTLOOK ON CRISPR CROP EDITING

Globus R., Qimron U. | J Cell Biochem. 2017 Jul 21

CD300F:IL-5 CROSS-TALK INHIBITS ADIPOSE TISSUE EOSINOPHIL HOMING AND SUBSEQUENT IL-4 PRODUCTION

Rozenberg P., Reichman H., Zab-Bar I., Itan M., Pasmanik-Chor M., Bouffi C., Qimron U., Bachelet I., Fulkerson P.C., Rothenberg M.E., Munitz A. | Sci Rep. 2017 Jul 19;7(1):5922

FULL SHUT-OFF OF ESCHERICHIA COLI RNA-POLYMERASE BY T7 PHAGE REQUIRES A SMALL PHAGE-ENCODED DNA-BINDING PROTEIN

Tabib-Salazar A., Liu B., Shadrin A., Burchell L., Wang Z., Wang Z., Goren M.G., Yosef I., Qimron U., Severinov K., Matthews S.J., Wigneshweraraj S. | Nucleic Acids Res. 2017 Jul 27;45(13):7697-7707

EXTENDING THE HOST RANGE OF BACTERIOPHAGE PARTICLES FOR DNA TRANSDUCTION

Yosef I., Goren M.G., Globus R., Molshanski-Mor S., Qimron U. | Mol Cell. 2017 Jun 1;66(5):721-728.e3. | Cover page – Molecular Cell June 1st 2017

SENSITIZING PATHOGENS TO ANTIBIOTICS USING THE CRISPR-CAS SYSTEM

Goren M., Yosef I., Qimron U. | Drug Resist Updat. 2017 Jan;30:1-6

PHENOTYPIC HETEROGENEITY IN A BACTERIOPHAGE POPULATION ONLY APPEARS AS STRESS-INDUCED MUTAGENESIS

Yosef I., Edgar R., Qimron U. | Curr Genet. 2016 Nov;62(4):771-773

REPEAT SIZE DETERMINATION BY TWO MOLECULAR RULERS IN THE TYPE I-E CRISPR ARRAY

Goren M.G., Doron S., Globus R., Amitai G., Sorek R., Qimron U. | Cell Rep. 2016 Sep 13;16(11):2811-2818

NATURAL SELECTION UNDERLIES APPARENT STRESS-INDUCED MUTAGENESIS IN A BACTERIOPHAGE INFECTION MODEL

Yosef I., Edgar R., Levy A., Amitai G., Sorek R., Munitz A., Qimron U. | Nat Microbiol. 2016 Apr 18;1(6):16047

COUNTERACTING SELECTION FOR ANTIBIOTIC-RESISTANT BACTERIA

Yosef I., Manor M., Qimron U. | Bacteriophage. 2016 Mar 7;6(1):e1096996

ADAPTATION IN CRISPR-CAS SYSTEMS

Sternberg S.H., Richter H., Charpentier E., Qimron U. | Mol Cell. 2016 Mar 17;61(6):797-808

PROGRAMMING BACTERIOPHAGES BY SWAPPING THEIR SPECIFICITY DETERMINANTS

Goren M.G., Yosef I., Qimron U. | Trends Microbiol. 23(12):744-746, 2015

TEMPERATE AND LYTIC BACTERIOPHAGES PROGRAMMED TO SENSITIZE AND KILL ANTIBIOTIC-RESISTANT BACTERIA

Yosef I., Manor M., Kiro R., Qimron U. | Proc Natl Acad Sci USA, 112(23):7267-7272, 2015

SPACER ADAPTATION BIASES EXPLAIN PREFERENCE FOR FOREIGN DNA IN CRISPR ADAPTATION

Levy A.*, Goren M.G.*, Yosef I., Auster O., Manor M., Amitai G., Edgar R., Qimron U.†, #, Sorek R.†, # *contributed equally; †joint supervision of work; #corresponding author | Nature, (article), 520(7548):505-510, 2015 | Highlighted in Nature Reviews Microbiology and in numerous press releases

MICROBIOLOGY NEWS AND VIEWS: HOW BACTERIA GET SPACERS FROM INVADERS

Yosef I. and Qimron U. | Nature, 519(7542):166-167, 2015

USING THE CRISPR/CAS SYSTEM TO POSITIVELY SELECT MUTANTS IN GENES ESSENTIAL FOR ITS FUNCTION

Yosef I., Goren M.G., Edgar R., Qimron U. | Methods in Molecular Biology, 1311:233-250, 2015

REVEALING BACTERIAL TARGETS OF GROWTH INHIBITORS ENCODED BY BACTERIOPHAGE T7

Molshanski-Mor S., Yosef I., Kiro R., Edgar R., Manor M., Gershovits M., Laserson M., Pupko T., Qimron U. | Proc Natl Acad Sci USA, 111(52):18715–18720, 2014

DIFFERENT APPROACHES FOR USING BACTERIOPHAGES AGAINST ANTIBIOTIC-RESISTANT BACTERIA

Yosef I., Kiro R., Molshanski-Mor S., Edgar R., Qimron U. | Bacteriophage, 4(1):e28491, 2014

EFFICIENT ENGINEERING OF A BACTERIOPHAGE GENOME USING THE TYPE I-E CRISPR-CAS SYSTEM

Kiro R., Shitrit D., Qimron U. | RNA Biology, 11(1):42-4, 2014

GENE PRODUCT 0.4 INCREASES BACTERIOPHAGE T7 COMPETITIVENESS BY INHIBITING HOST CELL DIVISION

Kiro R., Molshanski-Mor S., Yosef I., Milam S.L., Erickson H.P., Qimron U. | Proc Natl Acad Sci USA, 110(48):19549-54, 2013. Recommended by F1000

DNA MOTIFS DETERMINING THE EFFICIENCY OF ADAPTATION INTO THE ESCHERICHIA COLI CRISPR ARRAY

Yosef I., Shitrit D., Goren M.G., Burstein D., Pupko T., Qimron U. | Proc Natl Acad Sci USA, 110(35):14396-401, 2013

CRISPR ADAPTATION IN ESCHERICHIA COLI TYPE I-E SYSTEM

Kiro R., Goren M.G., Yosef I., Qimron U. | Biochemical Society Transactions, 41(6):1412-5, 2013

DISCOVERY OF FUNCTIONAL TOXIN/ANTITOXIN SYSTEMS IN BACTERIA BY SHOTGUN CLONING

Sberro H.*, Leavitt A.*, Kiro R.*, Koh E., Peleg Y., Qimron U., Sorek R. *contributed equally | Mol Cell, 50(1):136-48, 2013. Recommended by F1000

EXPERIMENTAL DEFINITION OF A CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC DUPLICON IN ESCHERICHIA COLI

Goren M.G., Yosef I., Auster O., Qimron U. | Journal of Molecular Biology, 423(1):14-6, 2012

THE BACTERIAL CRISPR/CAS SYSTEM AS ANALOG OF THE MAMMALIAN ADAPTIVE IMMUNE SYSTEM

Goren M.G., Yosef I., Edgar R., Qimron U. | RNA Biology, 9(5):549-54, 2012

PROTEINS AND DNA ELEMENTS ESSENTIAL FOR THE CRISPR ADAPTATION PROCESS IN ESCHERICHIA COLI

Yosef I., Goren M.G., Qimron U. | Nucleic Acids Research, 40(12):5569-76, 2012. Recommended by F1000

REVERSING BACTERIAL RESISTANCE TO ANTIBIOTICS BY PHAGE-MEDIATED DELIVERY OF DOMINANT SENSITIVE GENES

Edgar R., Friedman N., Molshanski-Mor S., Qimron U. | Applied and Environmental Microbiology, 78(3):744-51, 2012 | Highlighted in Nature Reviews Microbiology (PDF), Nature Medicine (PDF), Wall Street Journal (PDF), and international and local press

HTPG IS ESSENTIAL FOR ACTIVITY OF THE ESCHERICHIA COLI CRISPR/CAS SYSTEM

Yosef I., Goren M. G., Kiro R., Edgar R., Qimron U. | Proc Natl Acad Sci USA, 108(50):20136-41, 2011

E. COLI CRISPR SYSTEM PROTECTS FROM Λ LYSOGENIZATION, LYSOGENS, AND PROPHAGE INDUCTION

Edgar R., Qimron U. | J. Bacteriology, 192(23):6291-4, 2010

Thou shalt not cleave DNA-only repress transcription: A compact Cas protein representing a new CRISPR-Cas subtype

Mahata T and Qimron U. | Mol Cell, 82(23):4403-4404, 2022